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多基因适应导致高原藏族具有较高的生殖适合度(王勇)
2024-02-04 | 编辑:

  The adaptation of Tibetans to high-altitude environments has been studied extensively. However, the direct assessment of evolutionary adaptation, i.e., the reproductive fitness of Tibetans and its genetic basis, remains elusive. Here, we conduct systematic phenotyping and genome-wide association analysis of 2,252 mother-newborn pairs of indigenous Tibetans, covering 12 reproductive traits and 76 maternal physiological traits. Compared with the lowland immigrants living at high altitudes, indigenous Tibetans show better reproductive outcomes, reflected by their lower abortion rate, higher birth weight, and better fetal development. The results of genome-wide association analyses indicate a polygenic adaptation of reproduction in Tibetans, attributed to the genomic backgrounds of both the mothers and the newborns. Furthermore, the EPAS1-edited mice display higher reproductive fitness under chronic hypoxia, mirroring the situation in Tibetans. Collectively, these results shed new light on the phenotypic pattern and the genetic mechanism of human reproductive fitness in extreme environments. 

    

  Publication: 

  Current Biology, Volume 33, Issue 19, 9 October 2023, Pages 4037-4051.e5  

  http://dx.doi.org/10.1016/j.cub.2023.08.021 

    

  Author: 

  Yaoxi He 

  State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 

   

  Yongbo Guo 

  State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 

  Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing 100101, China 

   

  Wangshan Zheng 

  State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 

  Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing 100101, China 

   

  Tian Yue 

  State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 

  Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing 100101, China 

   

  Hui Zhang 

  State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 

  State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming 650000, China 

   

  Bin Wang 

  Fukang Obstetrics, Gynecology and Children Branch Hospital, Tibetan Fukang Hospital, Lhasa 850000, China 

   

  Zhanying Feng 

  CEMS, NCMIS, MDIS, Academy of Mathematics & Systems Science, Chinese Academy of Sciences, Beijing 100080, China 

   

  Ouzhuluobu 

  Fukang Obstetrics, Gynecology and Children Branch Hospital, Tibetan Fukang Hospital, Lhasa 850000, China 

  High Altitude Medical Research Center, School of Medicine, Tibetan University, Lhasa 850000, China 

   

  Chaoying Cui 

  Fukang Obstetrics, Gynecology and Children Branch Hospital, Tibetan Fukang Hospital, Lhasa 850000, China 

  High Altitude Medical Research Center, School of Medicine, Tibetan University, Lhasa 850000, China 

   

  Kai Liu 

  State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 

   

  Bin Zhou 

  State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 

  Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing 100101, China 

    

  Xuerui Zeng 

  State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 

  Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing 100101, China 

    

  Liya Li 

  State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 

    

  Tianyun Wang Department of Medical Genetics, Center for Medical Genetics, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China 

    

  Yong Wang 

  CEMS, NCMIS, MDIS, Academy of Mathematics & Systems Science, Chinese Academy of Sciences, Beijing 100080, China 

  Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming 650223, China 

  Email: ywang@amss.ac.cn 

   

  Chao Zhang 

  Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China 

    

  Shuhua Xu 

  State Key Laboratory of Genetic Engineering, Center for Evolutionary Biology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200438, China 

  Human Phenome Institute, Zhangjiang Fudan International Innovation Center, and Ministry of Education Key Laboratory of Contemporary Anthropology, Fudan University, Shanghai 201203, China 

    

  Xuebin Qi 

  State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 

  Fukang Obstetrics, Gynecology and Children Branch Hospital, Tibetan Fukang Hospital, Lhasa 850000, China 

  State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming 650000, China 

   

  Bing Su 

  State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 

  Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming 650223, China 

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